Longitudinal associations between ambient air pollution and insulin sensitivity: results from the KORA cohort study

BackgroundImpaired insulin sensitivity could be an intermediate step that links exposure to air pollution the development of type 2 diabetes. However, longitudinal associations with remain unclear. Our study investigated long-term degree and rate change sensitivity.MethodsIn this study, we analysed data from Cooperative Health Research in Region Augsburg (KORA) cohort Augsburg, Germany, which recruited participants aged 25–74 years survey between 1999 2001 (KORA S4), two follow-up examinations 2006–08 F4) 2013–14 FF4). Serum concentrations fasting glucose, homoeostasis model assessment resistance (HOMA-IR, a surrogate measure sensitivity) ?-cell function (HOMA-B, marker for secretion) were assessed at up three visits 2014. Annual average pollutant residence estimated by land-use regression models. We examined repeatedly biomarker levels using mixed-effects models, annual biomarkers quantile models.FindingsAmong 9620 observations 4261 KORA cohort, included 6008 (62·5%) 3297 (77·4%) our analyses. Per IQR increment concentrations, HOMA-IR significantly increased 2·5% (95% CI 0·3 4·7) coarse particulate matter, 3·1% (0·9 5·3) PM2·5, 3·6% (1·0 6·3) PM2·5absorbance, 3·2% (0·6 5·8) nitrogen dioxide, borderline 2·2% (–0·1 4·5) ozone, whereas it did not increase whole range ultrafine particles. Similar positive slightly smaller magnitude observed HOMA-B levels. In addition, positively associated HOMA-IR, HOMA-B, insulin. Neither level nor glucose exposure.InterpretationOur indicates contribute resistance, is one key factors pathogenesis diabetes.FundingGerman Federal Ministry Education Research. Impaired sensitivity. Among exposure.